Selected Literature | A Comprehensive Review of Past High‑Impact Papers, with an Average Impact Factor of 8.098!

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　　According to recent statistics, among the publications that have cited Life-iLab products, the highest impact factor recorded in previous years was 69.054, with an average impact factor as high as 8.098. We sincerely thank you for your attention and support; HeYuan Li Ji will continue to empower researchers worldwide.

　　The following are excerpts from high‑impact publications; for a more comprehensive list, please refer to… WeChat Official Account or Official website

Display of Selected High-Scoring Papers

1. Impact Factor (IF): 69.504

Title: Brown-fat-mediated tumour suppression by cold-altered global metabolism

Journal: Nature

Impact Factor: 69.504

Publication date: 2022-08-03

Affiliations: Karolinska Institute (Sweden), Fudan University, Shandong University, Wenzhou Medical University, and others.

DOI: https://www.nature.com/articles/s41586-022-05030-3

Article Summary: This study is the first to demonstrate that cold exposure enhances glucose uptake in brown adipose tissue while inhibiting glucose uptake in tumor cells, thereby suppressing tumor growth. These findings underscore the critical role of glucose metabolism in tumorigenesis, elucidate the effects of cold exposure on tumor tissues and its underlying mechanisms, and propose “cold therapy” as a potential anti‑tumor strategy.

II. Impact Factor (IF): 66.850

Title: Large-Scale Multiplexed Mosaic CRISPR Perturbation in the Whole Organism

Journal: Cell

Impact Factor: 66.850

Publication date: 2022-07-22

Affiliation: School of Life Science, ShanghaiTech University

DOI: https://doi.org/10.1016/j.cell.2022.06.039

Article Summary: This paper reports a novel mouse gene‑targeting technology, iMAP (inducible Mosaic Animal for Perturbation), which rapidly elucidated the essential functions of 90 genes across 39 tissue types and generated the world’s first “perturbation atlas” for mice.

3. Impact Factor (IF): 41.582

Title: Local hyperthermia therapy induces browning of white fat and treats obesity

Journal: Cell – Cover Article

Impact Factor: 41.582

Publication date: 2022-03-04

Affiliation: School of Life Sciences, East China Normal University; Sixth People’s Hospital of Shanghai Jiao Tong University

DOI: https://doi.org/10.1016/j.cell.2022.02.004

Article Summary: This study innovatively demonstrates that, in addition to cold stimulation, beige adipose tissue can sense localized mild heat and activate thermogenesis via HSF1, thereby safely and effectively counteracting and treating obesity while ameliorating metabolic disturbances such as insulin resistance and hepatic lipid accumulation. Furthermore, the research is the first to identify the HSF1–A2B1 transcriptional axis at the genomic level, further refining the HSF1‑mediated metabolic regulatory network. Moreover, a large-scale population study has established a clear association between HSF1 and metabolic traits, offering new therapeutic targets and strategies for obesity intervention.

IV. Impact Factor (IF): 19.319

Title: Dietary ketone body-escalated histone acetylation in megakaryocytes alleviates chemotherapy-induced thrombocytopenia

Journal: Science Translational Medicine – Cover Article

Impact Factor: 19.319

Publication date: 2022-11-30

Affiliations: Fudan University, Longyan First Hospital Affiliated to Fujian Medical University, Tongji University

DOI: http://doi.org/10.1126/scitranslmed.abn9061

Article Summary: This study is the first to demonstrate that a ketogenic diet elevates circulating β‑OHB levels, with ketone bodies entering megakaryocytes via MCT1‑dependent transport. There, they modulate platelet‑producing gene expression through histone acetylation, thereby increasing platelet counts. These findings elucidate how alterations in megakaryocyte metabolism influence thrombopoiesis and reveal the underlying mechanisms, while also proposing, from a translational medicine perspective, a safe and cost‑effective “ketogenic therapy” for treating chemotherapy‑induced thrombocytopenia (CIT).

5. Impact Factor (IF): 41.582

Title: Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

Journal: Cell

Impact Factor: 41.582

Publication date: 2022-03-09

Affiliation: Fudan University

DOI: https://doi.org/10.1016/j.cell.2022.03.009

Article Summary: This study demonstrates that this bispecific antibody can be efficiently delivered to the lungs via inhalation and exhibits remarkable neutralizing breadth and therapeutic efficacy in a mouse model of SARS‑CoV‑2 infection. Importantly, the research also elucidated an uncommon yet highly conserved cryptic epitope within the spike protein trimer interface, which could have implications for the design of broadly protective SARS‑CoV‑2 vaccines and therapeutics.

6. Impact Factor (IF): 38.104

Title: SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4 (CKAP4)

Journal: Signal Transduction and Targeted Therapy

Impact Factor: 38.104

Publication date: 2022-09-22

Affiliation: Department of Physiology and Pathology, School of Basic Medicine, Tianjin Medical University

DOI: https://www.nature.com/articles/s41392-022-01183-9

Article Summary: Numerous studies have shown that ACE2 is the primary receptor mediating SARS‑CoV‑2 entry into cells; however, ACE2 is expressed at low levels or not at all in human endothelial cells. Furthermore, membrane proteomics failed to detect any interaction between ACE2 and the Spike protein, and DX600 did not inhibit Spike‑induced vWF secretion, thereby reinforcing the possibility that other potential receptors may underlie Spike‑mediated thrombogenesis. The authors identified CKAP4 in endothelial cells as a novel receptor for the Spike protein, capable of triggering vWF release and thrombus formation, thus offering new therapeutic targets and strategies for patients with SARS‑CoV‑2‑associated thrombotic complications.

VII. Other…
1. IF: 27.287, Cell Metabolism, DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing, DOI: https://doi.org/10.1016/j.cmet.2021.09.008

2. IF: 25.617, Cell Research, A novel STING agonist–adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits, and non-human primates, DOI: https://doi.org/10.1038/s41422-022-00612-2

3. IF: 19, J Clin Invest, Targeting fibrinogen-like protein 1 enhances immunotherapy in hepatocellular carcinoma, DOI: https://www.jci.org/articles/view/164528

4. IF: 13.312, Cancer Research, TET2 suppresses VHL deficiency-driven clear cell renal cell carcinoma by inhibiting HIF signaling, DOI: https://doi.org/10.1158/0008-5472.CAN-21-3013

5. IF: 13.3, Translational Research, Defining the Sensitivity Landscape of EGFR Variants to Tyrosine Kinase Inhibitors, DOI: https://doi.org/10.1016/j.trsl.2022.11.002

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