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Can mycoplasma contamination be detected with the naked eye?
Publication date:2026-10-29
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Yes, provided your eyes have 20‑megapixel resolution and a 4,000‑fold zoom capability. Generally, cells contaminated with mycoplasma exhibit poorer growth; visually, it’s often difficult to distinguish whether the issue is mycoplasma contamination or simply an excess of salt added to the culture medium during preparation. The definitive diagnosis usually relies on PCR or staining assays. However, once contamination occurs, it’s best to discard the culture and verify that your serum is safe.
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